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Chemotherapy Vomiting
24: Pharmacol Biochem Behav 2003 Feb;74(3):691-9
Related
Articles, Links
The effect of electroacupuncture
as an adjunct on cyclophosphamide-induced emesis in
ferrets.
Lao L, Zhang G, Wong RH, Carter AK, Wynn RL, Berman BM.
Complementary Medicine Program, Department of Family
Medicine, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA
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The effect of electroacupuncture
(EA) on cyclophosphamide-induced emesis in ferrets
was studied at acupuncture point Neiguan (P6) with
various electrical stimulation parameters (5-100 Hz, 1.5-3 V, 5-20 min,
n=6/group). The combination therapy of EA (100 Hz, 1.5 V and 10 min) with the
lower doses of ondansetron (0.04 mg/kg), droperidol (0.25 mg/kg) and metoclopramide
(2.24 mg/kg) significantly reduced the total number of emetic episodes by 52%,
36% and 73%, respectively, as well as the number of emetic episodes in the
first phase as compared to the sham acupuncture control (P<.01). These
EA/drug combinations also showed a significant effect in preventing emesis as
compared to either EA or drug alone (P<.05). The present study suggests that
acupuncture may be useful as an adjunctive therapy in the treatment of
chemotherapy-induced emesis.
PMID: 12543236
[PubMed - in process]
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